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The most common side effects with GLP-1 receptor agonists (which may affect more than 1 in 10 people) include problems with the digestive system, such as diarrhoea and nausea (feeling sick)
56 reported an effect of hepatic FGF21 in inducing WAT lipolysis, suggesting that the early lipolytic effect of G49 can be boosted by liver-derived FGF21 whose increase in plasma was detected from 12 h post-injection peaking at 72 h
doi: 10.1046/j.1432-1327.2001.02329.x 139
Therefore, further studies to clarify the metabolic pathways involved in initiating and maintaining the tolerogenic or immunogenic states of dendritic cells and macrophages are relevant to understanding adaptive immune outcomes in disease resolution or progression related to efferocytosis defects